Thursday, February 28, 2013

New cars increasingly out of reach for many

Looking to buy a new car, truck or crossover? You may find it more difficult to stretch the household budget than you expected, according to a new study that finds median-income families in only one major U.S. city actually can afford the typical new vehicle.

The typical new vehicle is now more expensive than ever, averaging $30,550 in 2012, according to TrueCar.com data, and heading up again as makers curb the incentives that helped make their products more affordable during the recession when they were desperate for sales.

According to the 2013 Car Affordability Study by Interest.com, only in Washington, D.C., could the typical household swing the payments, the median income there running $86,680 a year. At the other extreme, Tampa was at the bottom of the 25 large cities included in the study, with a median household income of $43,832.

The study looked at a variety of household expenses, such as food and housing, and when it comes to purchasing a new vehicle, it considered more than just the basic purchase price, down payment and monthly note, factoring in such essentials as taxes and insurance.

Bottom line? A buyer in the capital can purchase a car with a sticker price of $31,940, slightly more than the new vehicle average for the 2013 model year and about what it would cost for a mid-range Ford Fusion sedan or a stripped-down BMW X1 crossover. The buyer in Tampa? They?ll just barely cover the cost of a basic Kia Rio, with $14,516 to spend.

More from The Detroit Bureau: Hyundai settles lawsuit for false mileage claims

?If you live in New York City or San Francisco, you?re probably going to have to pay a lot for housing, but you don?t have to pay a lot for a car,? said Mike Sante, the managing editor of Interest.com, a financial decision-making website.

Affordability has been a matter of growing concern for the auto industry in recent years as prices have continued to move upward. Even the most basic of today?s cars are generally loaded with features that were once found on high-line models a few decades back ? if they were available at all ? such as air conditioning, power windows, airbags and electronic stability control, as well as digital infotainment systems. They also have to meet ever tougher federal safety, emissions and mileage standards that have added thousands to the typical price tag.

?The average compact car of today has the features of a midsize model somebody might be trading in ? but it may be just as expensive,? said David Sargent, director of automotive operations for J.D. Power and Associates.

That is one reason why many buyers have been downsizing in recent years, said Bill Fay, general manager of Toyota, though he added that ?there is still a lot of affordability in the marketplace.?

Perhaps, but industry planners have come to recognize that they are targeting a much smaller segment of the American public than in decades past. That?s one reason why most manufacturers are offering more downsized models.

More from The Detroit Bureau: Consumer Reports names its 'Top Picks'

They also are working with their dealers to offer certified pre-owned programs where buyers can stretch their budget by purchasing a two- or three-year-old vehicle that has gone through an extensive inspection and, if necessary, repairs and replacements. Such vehicles may cost slightly more than a conventional used model but usually include a like-new warranty.

While the typical new vehicle will likely nudge up this year, Interest.com editor Sante stressed that car costs are one of the most controllable parts of a household?s budget. ?You?re better off driving something more affordable and saving or investing the difference.?

If the typical new car costs $30,550, with an average monthly payment of $550, the five cities most able to meet ? or come close ? are:

1) Washington, D.C.
Average Household Income: $86,680
Affordable Purchase Price: $31,940
Maximum monthly payment: $628

2) San Francisco
Average Household Income: $71,975
Affordable Purchase Price: $26,786
Maximum monthly payment: $537

3) Boston
Average Household Income: $69.455
Affordable Purchase Price: $26,025
Maximum monthly payment: $507

4) Baltimore
Average Household Income: $65,463
Affordable Purchase Price: $24,079
Maximum monthly payment: $468

5) Minneapolis
Average Household Income: $63,352
Affordable Purchase Price: $24,042
Maximum monthly payment: $470

At the other end of the scale, those five cities least able to handle a car payment are:

21) Phoenix
Average Household Income: $50,058
Affordable Purchase Price: $17,243
Maximum monthly payment: $348

22) San Antonio
Average Household Income: $48,699
Affordable Purchase Price: $17,137
Maximum monthly payment: $334

23) Detroit
Average Household Income: $48,968
Affordable Purchase Price: $17,093
Maximum monthly payment: $332

24) Miami
Average Household Income: $45,407
Affordable Purchase Price: $15,188
Maximum monthly payment: $295

25) Tampa
Average Household Income: $43,832
Affordable Purchase Price: $14,516
Maximum monthly payment: $282

More from The Detroit Bureau

Copyright ? 2009-2013, The Detroit Bureau

Source: http://www.nbcnews.com/business/new-cars-increasingly-out-reach-many-americans-1C8573730

kristen stewart Shirley Bassey adele Oscars 2013 barcelona vs real madrid renee zellweger catherine zeta jones

Samsung ATIV SmartPC Pro 700T (XE700T1C-A01US)


The Samsung ATIV SmartPC Pro 700T traces its roots back to the Samsung Series 7 Slate (700T1A), one of the earliest slate PCs in the iPad-inspired wave of tablets with laptop components. This new version adopts the ATIV SmartPC name, and adds a docking keyboard for laptop functionality, but the detachable tablet has all the traits of its predecessor, with Intel Core i5 processing, Windows 8, and a healthy collection of features.

Design
The ATIV SmartPC Pro 700T is a Windows 8 tablet with a design in the same group of devices as the Microsoft Surface Windows 8 Pro or the Acer Iconia W700-6465, packing laptop components into a detachable tablet. This stands in contrast to cheaper Atom-powered tablets like the HP Envy X2 (11-g012nr), which offer a laptop-like form factor, but a limited 32-bit version of Windows 8 with less processing power overall.

Unlike other docking tablets, the ATIV SmartPC has no secondary battery in the docking keyboard, meaning that using the keyboard will not lengthen the usable life of the tablet. Despite the lack of a second battery, the keyboard is weighted to alleviate some of the balance issues seen in dockable tablet designs, and it also boasts a full-size chiclet keyboard and touchpad. With the tablet docked, you'll be able to work on the ATIV Smart PC as easily as on a regular laptop.

The tablet alone measures 0.5 by 11.6 by 7.2 inches (HWD) and weighs a reasonable 1.9 pounds. Add the docking keyboard and the thickness doubles to a full inch, and adds more than a pound and a half of weight (for a total weight of 3.5 pounds). The 11.6-inch screen has 10-finger touch support and compatibility with Samsung's included S-Pen digital stylus. It sports a 1,920-by-1,080 resolution similar to the Sony VAIO Duo 11 (D11213CX). It also has backlighting, with up to 400-nit brightness for visibility and use in direct light or out in sunlight. Two built-in speakers offer stereo sound, but the sound they produce is thin and wimpy. For the most part, you'll want to use the tablet with headphones.

Features
The ATIV Smart PC Pro 700T may not offer the selection of ports and connections you'd expect on a full-fledged laptop, but it's par for the course for detachable tablets. It's equipped with one full-size USB 3.0 port, a headset jack, a microSD card slot, and micro HDMI port. For network connectivity, the internal 802.11n Wi-Fi should do the trick without a hiccup. Bluetooth 4.0 is available for pairing peripherals wirelessly, and WiDi (Wireless DIsplay) lets you stream HD video to any TV through a WiDi adapter, like the Belkin ScreenCast. On the docking keyboard, you'll find two additional USB ports (of the 2.0 variety), bringing the total number of accessible ports to three.

The tablet features front- and back-facing cameras, with a 2.0 megapixel webcam in front for Skype or similar video chat, and a 5.0 megapixel camera in back for snapping photos or shooting video. A 128GB solid-state drive (SSD) provides speedy performance, with 60GB free for storage.

In addition to the standard preinstalled software you'll find on most Windows 8 laptops and tablets?Microsoft Office starter 2010 and Skype, but also Evernote, Netflix, and Amazon Kindle Reader?you'll also get a 30-day trial of Norton Internet Security and Online Backup, the touch-friendly Fresh Paint, Music Maker Jam, Jamie Oliver's Recipes, Merriam-Webster Dictionary, and Plants vs. Zombies. Samsung also offers several proprietary apps, many carried over from the Samsung Galaxy Note and Galaxy Tab products, such as S Note and Mini S Note, S Camera, S Gallery, S Player, and the Samsung Signature Store. Samsung also offers a customer service app, and covers the ATIV SMart PC Pro 700T with a one-year warranty on parts and labor.

Performance
Samsung ATIV SmartPC Pro 700T (XE700T1C-A01US) The ATIV SmartPC Pro 700T has the potent combination of a dual-core Intel Core i5-3317U paired with 4GB of RAM, with an added performance boost from the 128GB SSD. This resulted in performance that's on par with mainstream ultrabooks. The ATIV SmartPC Pro 700T's PCMark 7 score of 4,471 points is in line with the Acer W500 (4,496 points), though it does fall slightly behind the Microsoft Surface Pro (4,768 points) and the Sony Duo 11 (4,648 points). The difference is stark, however, when compared to the Atom-powered tablets like the HP Envy X2, which scored only 1,429 points. In Cinebench, the performance was again nearly identical to other Core i5-equipped systems, with a score of 2.38 points.

Samsung ATIV SmartPC Pro 700T (XE700T1C-A01US)

Likewise, the ATIV SmartPC Pro 700T made quick work of our multimedia tests, completing the Handbrake video test in 1 minute 30 seconds?falling neatly between the Acer W500 (1:43) and Sony Duo 11 (1:25). It also finished Photoshop in a respectable 6 minutes 20 seconds. The integrated Intel HD Graphics 4000 won't get you very far with games like Skyrim, but the included Plants vs. Zombies should run just fine, and you could probably run Team Fortress 2 or Civilization V on it without much difficulty.

The ATIV SmartPC Pro 700T lasted 5 hours 12 minutes our battery rundown test, and convertible laptops, like the Microsoft Surface Pro and Acer Iconia W700-6465, produced slightly better scores (5:28 and 6:34, respectively). Smaller tablets usually last longer, like the HP Envy X2 (7:08 alone, 12:34 with the secondary battery) thanks to the use of small low-powered Atom processors designed for netbooks and tablets.

In terms of performance and battery-life, the Samsung ATIV Smart PC Pro 700T is similar to our current Editors' Choice, the Microsoft Surface Windows 8 Pro, though the Surface Pro stays our top pick for its innovative design. As a follow-up to the Series 7 Slate (700T1A), the ATIV Smart PC Pro 700T is more than capable, replacing a desktop dock with a laptop-style docking keyboard that lets you take your productivity on the road, and offering a combination of performance and battery life that's hard to ignore.

BENCHMARK TEST RESULTS:

COMPARISON TABLE
Compare the Samsung ATIV SmartPC Pro 700T (XE700T1C-A01US) with several other products side by side.

More laptop reviews:
??? Samsung ATIV SmartPC Pro 700T (XE700T1C-A01US)
??? Dell Latitude 6430u
??? HP EliteBook 2170p
??? Asus Zenbook Prime Touch UX31A-BHI5T
??? Toshiba Satellite C875-S7340
?? more

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/PpMDmSXgyaE/0,2817,2416024,00.asp

seal team 6 touch nitrous oxide rihanna thug life tattoo arizona governor patrick witt leprosy

Vt. lye victim gets new face at Boston hospital

(AP) ? Loved ones knew it was her at the hospital when they saw her teeth.

Carmen Blandin Tarleton's face was unrecognizable after the lye attack, burned away in the frenzy of an estranged husband's rage.

Nearly six years later, the Vermont nurse is celebrating a gift that has given her a new image following a full facial transplant this month.

Doctors at Brigham & Women's Hospital in Boston said at a Wednesday news conference that the 44-year-old's surgery included transplanting a female donor's facial skin to Tarleton's neck, nose and lips, along with facial muscles, arteries and nerves.

"I know how truly blessed I am, and will have such a nice reflection in the mirror to remind myself what selfless really is," Tarleton wrote on her blog Wednesday.

She did not attend the news conference but watched it during a live web broadcast. The hospital said it was not releasing a current picture of her.

Tarleton's sister, Kesstan Blandin, shared a statement from Tarleton that said she felt "really good and happy."

"I want to convey to the donor's family what a great gift they have given to me," the statement said. "...I feel strong and I am confident that I have the strength to deal with whatever comes my way."

The Thetford, Vt., woman suffered burns on more than 80 percent of her body and was left blind after her attacker beat her with a baseball bat and doused her with the industrial strength chemical in June 2007.

Tarleton, who once worked as a transplant nurse, has undergone more than 50 surgeries since then. The operations included skin grafts and work that has restored vision to one eye.

The latest surgery took 15 hours and included a team of more than 30 medical professionals. The lead surgeon, Bohdan Pomahac, called her injuries among the worst he's seen in his career.

"Carmen is a fighter," the doctor said. "And fight she did."

Pomahac's team has performed five facial transplants at the hospital. He said his team's latest patient is recovering well and is in great spirits as she works to get stronger.

Before the transplant, Tarleton drooled constantly because of scar tissue in her mouth. She also couldn't turn her head from side to side or lift her chin.

Pomahac said Tarleton was pleased when she saw her new face for the first time. Her appearance will not match that of the late donor's face, he said.

"I think she looks amazing, but I'm biased," the surgeon said with a smile.

The donor's family wants to remain anonymous now, but released a statement through a regional donor bank saying that her spirit would live on through Tarleton and three other organ recipients.

In 2009, Tarleton's now ex-husband Herbert Rodgers pleaded guilty to maiming her in exchange for a prison sentence of at least 30 years.

Police previously said Rodgers believed his wife was seeing another man and went to her house to attack him. Tarleton mistook the intruder for a burglar at first and told him he could have whatever he wanted. Then Rodgers launched into a fury, fracturing one of Tarleton's eye sockets and breaking her arm with the bat.

He had brought lye with him in a squeeze bottle and he poured it on Tarleton.

When police arrived, the brunette's heart-shaped face already was distorted, her skin turning brown. She was trying to crawl into a shower to wash away the chemical.

But now, the mother of two daughters talks about forgiveness and has a newly-published book called "Overcome: Burned, Blinded and Blessed."

"Forgiveness is about helping ourselves, not the people who hurt us," read an image on a website Wednesday that promotes her book.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2013-02-27-Lye%20Attack-Face%20Transplant/id-144c6e6927a74e5cb20b378712c27a7f

superbowl national anthem patriots vs giants super bowl superbowl halftime show papa johns guacamole recipe jason wu for target underwood

Wednesday, February 27, 2013

Tunisia: 4 in custody for politician's slaying

TUNIS, Tunisia (AP) ? Four suspects belonging to a radical Islamic group have been arrested for their alleged involvement in the murder of a leftist politician that plunged Tunisia into crisis, but the killer himself remains at large, the interior minister said Tuesday.

Ali Larayedh, who has been tapped to be the next prime minister, said the Tunisian suspects, some of whom had been arrested in the last 48 hours, were accomplices to the murder and that the identity of the assassin is known.

The assassination of Chokri Belaid, an opposition politician from the Popular Front coalition, occurred outside his home on Feb. 6. It shocked the country, and many blamed the Islamist-led governing coalition, unleashing days of protests. On Sunday, thousands demonstrated in downtown Tunis over the lack of results in the investigation.

Many have accused the moderate Islamist Ennahda Party, which dominates the government, of complicity in the attack, citing its alleged use of gangs to intimidate political opponents. But Ennahda has denied ever resorting to any violence and has vehemently condemned the assassination.

Larayedh, who is a member of Ennahda, did not identify the group he was holding responsible for the assassination, but denied there were any foreign links to the killing.

Since the overthrow of Tunisia's secular dictatorship in January 2011, there has been a rise in ultraconservative Muslims known as Salafis, some of whom have resorted to violence. On Sept. 14, a band attacked the U.S. Embassy and damaged the surroundings. Tunisia's government has blamed the radical Islamic group Ansar al-Shariah for that attack and said it is trying to track down its leader.

Larayedh said that he was holding Tuesday's news conference in response to pressure for results of the investigation and media leaks the night before that had erroneously claimed the murderer himself had been arrested.

"The investigation is ongoing, and I will give you the latest conclusions," he said. "We cannot give any details that would affect the inquiry."

The four suspects range in age from 26 to 34 and are part of a "radical religious group," the minister said, adding that one had confessed to accompanying the actual assassin. At least some of the others detained had been involved in checking out the site a few days before the attack, the minister said.

Belaid was shot four times as he got in his car outside his house. The suspect involved in the actual attack took part in a reenactment of the crime scene outside Belaid's home on Tuesday wearing a mask and under heavy police guard.

"It was an ignoble crime with repercussions on the country's security and social peace, and has threatened to take us into chaos and the unknown," Larayedh said at the press conference.

The assassination resulted in the resignation of the country's prime minister, and Larayedh has been appointed his successor to form a new coalition government.

Authorities also have discovered many weapons caches and clashed with militants crossing into the country from neighboring Algeria and Libya. Larayedh said he believes some of the weapons were to carry out terrorist attacks inside Tunisia, while others were en route from Libya to Islamist militants fighting in northern Mali.

Source: http://news.yahoo.com/tunisia-4-custody-politicians-slaying-151457552.html

Voting Locations atlanta falcons voting hours election results Doug Martin Barack Obama & Joe Biden Am I registered to vote

Cryopreservation: A chance for highly endangered mammals

Feb. 27, 2013 ? Oocytes of lions, tigers and other cat species survive the preservation in liquid nitrogen. Scientists of the Leibniz Institute for Zoo and Wildlife Research (IZW) in Berlin succeeded in carrying out cryopreservation of felid ovary cortex.

"We have successfully frozen and thawed oocytes in the ovary cortex of different cat species at minus 196 degrees Celsius. This freezing process and the storage of living cellular material in liquid nitrogen is called cryopreservation," said Caterina Wiedemann, doctoral candidate at the IZW.

The ovarian cortex is regarded as a reservoir of reproductive cells. It contains thousands of immature oocytes. Successful cryopreservation of ovarian tissue of wild cats is therefore a key element for the establishment of genome resource banks, an important tool for the preservation of genetic diversity. All felid species except for the domestic cats are listed on the Red List for endangered species of the International Union for Conservation of Nature (IUCN).

Taking a freezing procedure developed in human medicine as their model, scientists at the Department of Reproduction Biology of the IZW developed a method for cryopreserving the ovarian cortex of different cat species. In the original procedure, ovarian tissue of women who suffer from cancer is removed to avoid its damage by chemotherapy or radiotherapy. After successful tumor treatment the tissue is re-transplanted so that the normal female cycle, including fertility, can be restored. In the meantime, the tissue is conserved in liquid nitrogen. The IZW adapted this method to preserve female germ cells from feline species.

The particular challenge in the cryopreservation of ovarian cortex tissue comes from the fact that the cells are embedded in a very complex system. Ovarian cortex is composed of immature oocytes surrounded by small somatic cells, different connective tissue and blood vessel cells. In addition, the cellular properties of every species are unique, thus it not possible to develop a common freezing procedure applicable to all species. For the cat cells, the scientists of the IZW worked out a "slow" freezing protocol. The cortex was dissected into evenly chopped pieces, each 2 mm in diameter. The cellular material was frozen at a speed of 0.3 degrees per minute. Ethylene glycol and saccharose were used as cryoprotectant agents. To demonstrate their survival after thawing the ovaries, the cortex was cultured in a medium for up to 14 days before and after the freezing.

The IZW owns the genome resource bank ?Arche," which contains, inter alia, a variety of sperm samples of various wildlife species. The newly developed cryopreservation method will substantially improve the future storage of feline germ cells. ?This is a large step towards preserving biodiversity. In particular to endangered cat species the successful cryopreservation of female and male gametes is a ray of hope," commented the head of the department, Prof Dr Katarina Jewgenow (IZW).

In 2007 the IZW initiated the "Felid Gametes Rescue Project" in order to build up an European network for the extraction and storage of feline gametes, which are made available to breeding programmes of zoos. Within the framework of this project, different European zoos are sending ovaries and testes of big and small cats to the IZW in Berlin for research. The scientists involved are confident that these good results will encourage even more zoos to participate in the network.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by Forschungsverbund Berlin e.V. (FVB).

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Caterina Wiedemann, Jennifer Zahmel, Katarina Jewgenow. Short-term culture of ovarian cortex pieces to assess the cryopreservation outcome in wild felids for genome conservation. BMC Veterinary Research, 2013; 9 (1): 37 DOI: 10.1186/1746-6148-9-37

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/strange_science/~3/gD-2iNyP-Jk/130227101951.htm

Happy 4th of July 4th Of July Desserts fireworks fireworks 4th of July Andy Griffith joe johnson

Antioxidant improves donated liver survival rate to more than 90%

Feb. 25, 2013 ? Researchers from Italy have found that the antioxidant, N-acetylcysteine (NAC), when injected prior to harvesting of the liver, significantly improves graft survival following transplantation. Results published in the February issue of Liver Transplantation, a journal of the American Association for the Study of Liver Diseases (AASLD), suggest that the NAC effect on early graft function and survival is higher when suboptimal organs are used.

A 2010 World Health Organization (WHO) report estimates that 22,000 liver transplants were performed worldwide, with nearly 18,500 from deceased donors. According to the Organ Procurement and Transplantation Network (OPTN) close to 16,000 U.S. patients are currently on the waiting list for a liver. Nearly 18,500 deceased donor transplants were performed between January and October 2012 in the U.S. OPTN reports that roughly 7,000 livers were recovered from deceased donors during the same time period.

"Liver transplantation is the standard treatment for end-stage liver disease," explains lead author Dr. Francesco D'Amico from Padova University in Italy. "Antioxidants such as NAC could potentially reduce damage to deceased donor livers, improving graft function." Studies have shown that ischemia-reperfusion injury (IFI)-damage to the liver tissue when blood supply returns to the liver after lack of oxygen (ischemia)-often occurs during storage and preservation of donated livers, and impacts early graft function post-transplantation.

For the present study researchers assigned 140 organs to adult candidates with liver disease undergoing their first transplant. An NAC infusion of 30 mg/kg was administered to one hour prior to liver procurement and another infusion of 300 mg (150mg/kg liver weight) through the portal vein before cross-clamping. There were 69 transplant candidates who received an NAC infused organ and 71 patients who had a standard transplant without NAC.

Results indicate that graft survival rates at 3 and 12 months were 93% and 90%, respectively, for patients receiving NAC infused livers; rates were 82% and 70% in the control group. Post-transplant complication rates were 23% for the NAC group and 51% in the control group. Analysis of the 61 patients receiving suboptimal livers the incidence of organ dysfunction was lower in the NAC group compared to controls at 15% and 32%, respectively.

Dr. D'Amico concludes, "Our study was the first randomized trial to investigate the use of NAC antioxidant infusion during the liver procurement procedure. We propose that NAC be used during organ harvesting to improve liver transplantation outcomes, particularly with the increased use of suboptimal organs. NAC has a good safety profile and the very low cost per patient, make this protocol highly cost-effective in consideration of grafts survival, length of hospital stays and post operative complications. Moreover we are performing further analyses to determine beneficial effects on the other organ procured with NAC protocol."

In a related editorial published this month in Liver Transplantation the authors from the University of California, San Francisco (UCSF) and OneLegacy (Organ Procurement Organization, Los Angeles) highlight the importance and rarity of deceased organ donor research, such as the study by D'Amico et al., despite the fact that randomized clinical trials are essential to evidence-based medicine. Dr. Claus Niemann from the Department of Anesthesia and the Department of Surgery, Division of Transplantation at UCSF said, "Well-controlled deceased donor research is crucial to uncovering superior clinical practices that improve organ utilization and transplant outcomes. However, researchers are currently operating in a regulatory and legal vacuum since no review and oversight policies are established."

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by Wiley.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal References:

  1. Francesco D'Amico, Alessandro Vitale, Donatella Piovan, Alessandra Bertacco, Rafael Ramirez Morales, Anna Chiara Frigo, Domenico Bassi, Pasquale Bonsignore, Enrico Gringeri, Michele Valmasoni, Greta Garbo, Enrico Lodo, Francesco Enrico D'Amico, Michele Scopelliti, Amedeo Carraro, Martina Gambato, Alberto Brolese, Giacomo Zanus, Daniele Neri, Umberto Cillo. Use ofN-acetylcysteine during liver procurement: A prospective randomized controlled study. Liver Transplantation, 2013; 19 (2): 135 DOI: 10.1002/lt.23527
  2. Thomas Mone, John Heldens, Claus U. Niemann. Deceased Organ Donor Research: The Last Research Frontier? Liver Transplantation, 2013; 19 (2): 118 DOI: 10.1002/lt.23579

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/cW3DDVvCvl8/130225102531.htm

2013 srt viper scott walker recall fisker atlantic social darwinism jamie lynn spears wisconsin recall election april 4

Tuesday, February 26, 2013

U of M researchers identify genetic variation behind acute myeloid leukemia treatment success

U of M researchers identify genetic variation behind acute myeloid leukemia treatment success [ Back to EurekAlert! ] Public release date: 26-Feb-2013
[ | E-mail | Share Share ]

Contact: Amy Leslie
johns423@umn.edu
612-624-7654
University of Minnesota Academic Health Center

MINNEAPOLIS/ST. PAUL (February 26, 2013) Researchers from the College of Pharmacy and Medical School working within the Masonic Cancer Center, University of Minnesota, have partnered to identify genetic variations that may help signal which acute myeloid leukemia (AML) patients will benefit or not benefit from one of the newest antileukemic agents.

Their study is published today in Clinical Cancer Research.

In the latest study, U of M researchers evaluated how inherited genetic polymorphisms in CD33, a protein that naturally occurs in most leukemia cells, could affect clinical outcomes of patients treated with an existing chemotherapy drug, gemtuzumab ozogamicin (GO), an immuno-conjugate between anti-CD33 antibody and a cytotoxin known as calicheamicin, which binds to CD33 on leukemic cells. As GO is internalized by leukemia cells, the cytotoxin is released, causing DNA damage and generating leukemic cell death.

In recent clinical trials GO has been shown to induce remission and improve survival in subset of patients with AML, however there is wide inter-patient variation in response.

Jatinder Lamba, Ph.D., and colleagues identified and evaluated three genetic variations of CD33 in two groups of patients with pediatric AML one group that received the drug GO, and one group that did not. They found that specific genetic variation in CD33 that significantly affected the clinical outcome of AML patients who received GO based chemotherapy.

"Understanding how genetics play a role in how drugs work is extremely useful, particularly for a drug like GO which has shown a very heterogeneous response in AML patients," said Jatinder Lamba, Ph.D., the study's lead author and a researcher who holds appointments in both the College of Pharmacy and the Masonic Cancer Center, University of Minnesota. "Our latest findings lead us to believe that genetic variation in CD33 influences how AML patients' leukemic cell responds to GO."

AML is a cancer of the blood and bone marrow, and is the second most common form of leukemia in children. Though the most common type of treatment for AML is chemotherapy, Lamba says the disease remains hard to treat and newer, more effective therapies are needed.

"The overall goal of our study was to use genetic data to predict beneficial or adverse response to a specific drug, thus opening up opportunities to use this information for drug optimization to achieve maximum therapeutic efficacy and minimum toxicity. Our hope is that our research could serve as a marker of prognostic significance for clinicians to select the therapy that has the greatest odds of being effective for individual patients based on their CD33 genotype."

###

Other University of Minnesota researchers involved in the study include Leslie Mortland, M.D., from the University of Minnesota Medical School and Betsy Hirsch, Ph.D., from the Medical School and the Masonic Cancer Center, University of Minnesota.

The University of Minnesota College of Pharmacy, the only school of pharmacy in Minnesota, offers its program on the Twin Cities and Duluth campuses. Founded in 1892, the College of Pharmacy educates pharmacists and scientists and engages in research and practice to improve the health of the people of Minnesota and society. The college is part of the Academic Health Center, which is home to the University of Minnesota's six health professional schools and colleges as well as several health-related centers and institutes. Learn more at www.pharmacy.umn.edu.

The University of Minnesota Medical School, with its two campuses in the Twin Cities and Duluth, is a leading educator of the next generation of physicians. Our graduates and the school's 3,800 faculty physicians and scientists advance patient care, discover biomedical research breakthroughs with more than $180 million in sponsored research annually, and enhance health through world-class patient care for the state of Minnesota and beyond. Visit www.med.umn.edu to learn more.

Masonic Cancer Center, University of Minnesota is part of the University's Academic Health Center. It is designated by the National Cancer Institute as a Comprehensive Cancer Center. For more information about the Masonic Cancer Center, visit www.cancer.umn.edu or call 612-624-2620.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


U of M researchers identify genetic variation behind acute myeloid leukemia treatment success [ Back to EurekAlert! ] Public release date: 26-Feb-2013
[ | E-mail | Share Share ]

Contact: Amy Leslie
johns423@umn.edu
612-624-7654
University of Minnesota Academic Health Center

MINNEAPOLIS/ST. PAUL (February 26, 2013) Researchers from the College of Pharmacy and Medical School working within the Masonic Cancer Center, University of Minnesota, have partnered to identify genetic variations that may help signal which acute myeloid leukemia (AML) patients will benefit or not benefit from one of the newest antileukemic agents.

Their study is published today in Clinical Cancer Research.

In the latest study, U of M researchers evaluated how inherited genetic polymorphisms in CD33, a protein that naturally occurs in most leukemia cells, could affect clinical outcomes of patients treated with an existing chemotherapy drug, gemtuzumab ozogamicin (GO), an immuno-conjugate between anti-CD33 antibody and a cytotoxin known as calicheamicin, which binds to CD33 on leukemic cells. As GO is internalized by leukemia cells, the cytotoxin is released, causing DNA damage and generating leukemic cell death.

In recent clinical trials GO has been shown to induce remission and improve survival in subset of patients with AML, however there is wide inter-patient variation in response.

Jatinder Lamba, Ph.D., and colleagues identified and evaluated three genetic variations of CD33 in two groups of patients with pediatric AML one group that received the drug GO, and one group that did not. They found that specific genetic variation in CD33 that significantly affected the clinical outcome of AML patients who received GO based chemotherapy.

"Understanding how genetics play a role in how drugs work is extremely useful, particularly for a drug like GO which has shown a very heterogeneous response in AML patients," said Jatinder Lamba, Ph.D., the study's lead author and a researcher who holds appointments in both the College of Pharmacy and the Masonic Cancer Center, University of Minnesota. "Our latest findings lead us to believe that genetic variation in CD33 influences how AML patients' leukemic cell responds to GO."

AML is a cancer of the blood and bone marrow, and is the second most common form of leukemia in children. Though the most common type of treatment for AML is chemotherapy, Lamba says the disease remains hard to treat and newer, more effective therapies are needed.

"The overall goal of our study was to use genetic data to predict beneficial or adverse response to a specific drug, thus opening up opportunities to use this information for drug optimization to achieve maximum therapeutic efficacy and minimum toxicity. Our hope is that our research could serve as a marker of prognostic significance for clinicians to select the therapy that has the greatest odds of being effective for individual patients based on their CD33 genotype."

###

Other University of Minnesota researchers involved in the study include Leslie Mortland, M.D., from the University of Minnesota Medical School and Betsy Hirsch, Ph.D., from the Medical School and the Masonic Cancer Center, University of Minnesota.

The University of Minnesota College of Pharmacy, the only school of pharmacy in Minnesota, offers its program on the Twin Cities and Duluth campuses. Founded in 1892, the College of Pharmacy educates pharmacists and scientists and engages in research and practice to improve the health of the people of Minnesota and society. The college is part of the Academic Health Center, which is home to the University of Minnesota's six health professional schools and colleges as well as several health-related centers and institutes. Learn more at www.pharmacy.umn.edu.

The University of Minnesota Medical School, with its two campuses in the Twin Cities and Duluth, is a leading educator of the next generation of physicians. Our graduates and the school's 3,800 faculty physicians and scientists advance patient care, discover biomedical research breakthroughs with more than $180 million in sponsored research annually, and enhance health through world-class patient care for the state of Minnesota and beyond. Visit www.med.umn.edu to learn more.

Masonic Cancer Center, University of Minnesota is part of the University's Academic Health Center. It is designated by the National Cancer Institute as a Comprehensive Cancer Center. For more information about the Masonic Cancer Center, visit www.cancer.umn.edu or call 612-624-2620.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-02/uoma-uom022613.php

limbaugh aaron smith wilt chamberlain joe arpaio cat in the hat green eggs and ham wiz khalifa and amber rose

The Seedbed of Civic Involvement Otis White

Everything works better in cities with high levels of citizen involvement. Social scientists tell us that politics are kinder when more people pay attention to government and vote, and social problems are diminished when people are close to their neighbors. Quality of life improves when people support festivals and attend local concerts and shows. Cities look better if people turn out for neighborhood cleanups and park conservancy projects. And when trouble comes?a big local industry closes or a natural disaster strikes?people are far more likely to see things through when they?re involved and invested in the place they live.

If civic involvement can do all these things, then there?s really only one big question: Where do you begin? Assuming yours is not a place where people vote in high numbers, check up on their neighbors, and turn out in large numbers for cleanup projects, what can governments and civic organizations do to get it started?

Answer: They can help people find one another and get organized for any legitimate purpose: recreation, self-improvement, religious, family betterment, education. And then be patient.

This won?t satisfy impatient leaders who want people involved in high-level civic work . . .? now!? How about calling some town-hall meetings or starting a citizens commission? You can do that, and if you do it well, you might see some improvement in community involvement. But if you want deeper, long-term change?big shifts in how citizens relate to one another and to the community?you need to work on the seedbed of civic involvement, which is self-interest plus connection plus organization. Then trust that these seeds will grow into a more involved citizenry.

Why begin with the seedbed? Because most people who are leaders in their communities didn?t start out as involved citizens; they grew into the role. A few had jobs that took them into local politics or civic causes, but the vast majority came up through volunteer work. And their first experiences with volunteering were usually about things in their immediate areas of interest (family, home, recreation, etc.). Go through the biographies of your city?s elected officials and you?ll find many started out volunteering for the PTA and got drawn into school district issues, or were on a neighborhood association board and got interested in local politics, or were active in a bicycling club and got caught up in a campaign for bike lanes. Once they figured out how things worked in their community, they were hooked.

This, then, is one reason you start with the seedbed: Multiply the number of opportunities for volunteer leadership, and in time you?ll multiply the number of deeply involved civic leaders. It won?t happen quickly. And not all the seedlings will grow into city leaders; many will be happy to serve in the PTA for years, or organize neighborhood cookouts, or teach safety classes to generations of young cyclists.

And that brings us to the second reason for tending the seedbed: Just as healthy forests don?t need all trees to be tall, we don?t need only highly involved civic leaders. We need moderately involved citizens, too: People who vote, serve on PTA committees, volunteer as Scout leaders and soccer coaches, turn out for neighborhood projects, and make small donations to good causes. Just as leaders do, these people strengthen their communities.

I can see this in my own life. My mother belonged to a business women?s club that, as far as I could tell, functioned as a social organization that, on the side, gave out college scholarships. Mostly, though, it just met, listened to speakers, and socialized. The scholarships were a good thing for the community, helping a few deserving students along the way. But an even better thing may have been the connections that these women forged as they helped one another in their careers. Who knows how many of them stayed in my hometown because of this network, enriching the community?s human capital?

We?ve known about this link between social networks and healthy communities for more than a decade, since Harvard Professor Robert Putnam wrote his book ?Bowling Alone.? It was a convincing look at the decline of what Putnam called ?social capital,? the connections that people have with one another. Where Americans once played bridge in foursomes, bowled in leagues, and joined Kiwanis Clubs to meet other business people, we now spend time in cars commuting long distances or in front of TVs or home computers. Putnam learned that people still do bowl; they just don?t do so in leagues. Rather, most bowl alone or as couples. Without the leagues, the bridge parties, the Kiwanis Clubs, and all the other group activities, modern Americans don?t form relationships and work for common purposes as easily as they once did. And this, he warned, threatens healthy communities and democracy itself.

Putnam?s book was a brilliant but depressing analysis of the problem that didn?t give us many starting points for changing things. But a new book and a think-tank report from the U.K. do. They point us to simple ways for connecting people around shared interests, by using a few incentives and a little help.

The book is ?Unanticipated Gains? by Mario Luis Small, a sociology professor at the University of Chicago. As the title suggests, it was about something surprising: the rich networks of support that some families in New York developed when their children were young.

His study focused on mothers from a variety of socioeconomic backgrounds who had children in day care centers. Parents turn to centers, of course, for economic or professional reasons: They have to work or want to work, and they need a safe, nurturing place for their children for a portion of the day. You?d think that the interactions of mothers and fathers dropping off and picking up small children would be hurried and, therefore, not great for creating connections. But some centers, Small found, had very effective ways of bringing parents together and connecting them with the city around them.

The keys were that some centers required parents to do something in addition to leaving and picking up their children: organize a field trip, serve on a parents? advisory committee, raise money, and so on. And some were good at connecting parents with needs with resources elsewhere in the community. As a result, through these centers, some parents got a lot more than child care; they gained lifelong friends, new resources, and much closer connections with the community.

What was important, Small said, were the activities the parents were asked to do. If the work was organized by the parents themselves, which required understanding, and the interactions were repeated, which built trust, friendships grew even among parents who were not much alike. This is particularly important in multi-cultural communities where people often don?t recognize themselves in their neighbors.

And some of the centers were more than good facilitators, Small found. They were good brokers of information. That is, they could help parents find information and get help outside their neighborhoods, by showing them how to navigate the public school system, get help in domestic abuse cases, find doctors and hospitals, even get family tickets to museums and circuses.

What does this have to do with civic work? As my mother?s business women?s network did in my hometown, it made it far more likely these families would stay in New York and be successful there. It meant their children would also be more likely to succeed. And simply having a network of friends?and a stake in the city?meant for many that they would take greater ownership in and care of the community. People with friends are less likely to litter, deface property with graffiti, or ignore criminal activity. And they are more likely to vote, volunteer for good causes, and care about their neighbors.

And something else. This kind of self-interested volunteering teaches people the basics of leadership: organizing meetings, managing projects, finding resources, handling disputes, negotiating with other interests. Some will take these skills to larger venues.

With the New York day care centers, government had a hand in getting the parents connected. Centers that served low-income families and received state aid were required to have parent advisory committees. That incentive alone got some centers started in involving parents, although the smart ones went well beyond that.

Governments can?t require other forms of volunteerism, of course. All they can do is encourage and facilitate it. But that can be a powerful tool, as a report from a British think tank argues. The report is called ?Clubbing Together: The Hidden Wealth of Communities,? and it argues that ?casual connections? among citizens can be generated with little effort and cities can play a big role in doing so by making it easier for people to meet.

What are ?casual connections?? They could be anything from people playing bingo to weekend sports leagues (think of softball leagues here, soccer there). These connections introduce people to one another, promote ethnic understanding, create ?sentiments of trust, reciprocity, and purpose,? and in time ?spur members into social actions, such as voluntary work or charitable giving,? the report says. In other words, they act as seedbeds.

This brings me to the great opportunity for communities. They have lots of places for people to meet, from playgrounds and softball fields to libraries and community centers. And with a little imagination, they could multiply the number of meeting places tenfold: school cafeterias, museum lobbies, concert halls, city hall meeting rooms, college classrooms, YMCAs. There are private spaces too, such as coffee shops, apartment clubhouses, and (yes!) bowling alleys that could be induced to open their doors to citizens?and potential customers?if there were property tax breaks involved. We could also make it easy for groups to find these spaces, with online reservations. (Attention, community hackathons!)

But what about security and cleanup? Organizers could sign forms assuming responsibility for hauling out trash and locking the doors. Would it work? I?ve been involved in scores of public meetings in schools, churches, and recreation centers over the years. I?ve never seen a volunteer group?even an informal one?refuse to take these responsibilities seriously.

But there?s a lesson here too. Much like mulch in a real seedbed, trust is the ingredient that enriches civic seedbeds. Yes, once in a while, you will be disappointed when a group doesn?t clean up the school cafeteria as it promised. But as you?re obsessing about the few, be sure to look about you and see all the healthy trees that are growing up.

?

Photo by Pictoscribe licensed under Creative Commons.

Source: http://otiswhite.com/?p=273

catch me if you can delmon young arrested the raven the raven zerg rush david wilson playstation all stars battle royale

Monday, February 25, 2013

Bees use the 'force' to choose the best flowers, study finds

Bees can alter the electrical charge of the flowers they touch. A new study finds that bees use these electrical cues to help them choose flowers with the most nectar and pollen.

By Pete Spotts,?Staff writer / February 22, 2013

Bees learn to use electrical clues to choose which flower is the most promising target, according to a new study.

Vasily Fedosenko/Reuters/File

Enlarge

If you're a bee having a hard time finding that flower trying to tell you it's loaded with nectar and pollen, use the force, bee, use the force.

Skip to next paragraph

' + google_ads[0].line2 + '
' + google_ads[0].line3 + '

'; } else if (google_ads.length > 1) { ad_unit += ''; } } document.getElementById("ad_unit").innerHTML += ad_unit; google_adnum += google_ads.length; return; } var google_adnum = 0; google_ad_client = "pub-6743622525202572"; google_ad_output = 'js'; google_max_num_ads = '1'; google_feedback = "on"; google_ad_type = "text"; google_adtest = "on"; google_image_size = '230x105'; google_skip = '0'; // -->

For the first time, scientists have demonstrated that the interaction of charges that can build up naturally on bees and plants plays a role in helping the insects find the best flowers to nourish themselves and the hive.

Bees have long been known to use color, shape, patterns, and odor to identify their their floral targets. The new study, conducted by researchers at the University of Bristol in Britain, suggests that bees also use electrical cues. Based on the results, the researchers suggest that if bees approach a flower and sense a disturbance in the "force," they know another bee has beat them to the blossom.

From a bee's perspective, electrical cues are another tool that enables more-efficient foraging. The flower also benefits, according to University of Bristol biologist Daniel Robert, who oversaw the study.

"The last thing a flower wants is to attract a bee and then fail to provide nectar," he said in a prepared statement. Bees quickly learn which flowers are productive and which aren't. The ones that aren't are less likely to get visits and have their pollen spread to other flowers for reproduction. The electrical cues they receive from the flowers may represent a "come back later" signal.

Bees' ability to sense and respond to plants' electrical fields "is a remarkable finding, " says Mark Winston, a biologist at Simon Fraser University in Burnaby, B.C., and the author of a book on bee biology.

It represents another method "by which bees perceive the world around them and it adds another wonderful story that continues to deepen our understanding the co-evolved relationship between bees and flowers," he says.

For 30 years, some researchers have posited that electrostatic charges that can build up on bees play a role in the bees taking up and transporting pollen ? a kind of small-scale static cling. They also found that the voltage associated with a flower changes as it's pollinated.

But the experiments by Dr. Robert and colleagues suggest that electricity represents a medium for conveying information between flower and bee before the bee lands.

Previous studies had indicated that bees carry a positive electrical charge with voltages that in some cases can reach as high as 200 volts. They build up the charge as they fly. With their roots in the earth, plants tend to carry a negative charge.

Source: http://rss.csmonitor.com/~r/feeds/science/~3/8TgV6CvU7ss/Bees-use-the-force-to-choose-the-best-flowers-study-finds

ricky williams kurt warner kurt warner missouri primary minnesota caucus knowshon moreno knowshon moreno

Sequestration affecting congressional hiring, Rep. Goodlatte says (Washington Post)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories Stories, RSS and RSS Feed via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/287079151?client_source=feed&format=rss

lara logan manu ginobili sports illustrated swimsuit 2012 aretha franklin whitney houston paul williams paul babeu kevin costner

Egypt to reopen IMF loan talks next month as crisis bites

CAIRO (Reuters) - Egypt will reopen talks with the IMF next month on a $4.8 billion loan, a minister said on Monday, and the government laid out plans to reverse a slide in currency reserves and tackle the dire state of public finances.

A revised government economic reform programme, essential for securing a lifeline from the International Monetary Fund, called for a levy on stock market transactions and a flat 25 percent tax rate for Egyptian companies, many of which are struggling for survival in a national economic crisis.

Investment Minister Osama Saleh expressed hope that help was on its way as Egypt battles with a falling currency and a budget deficit soaring to unaffordable levels.

"There have been pledges of international and regional support to Egypt and most of these are in progress," he told a conference in Dubai. "Negotiations with the IMF over the $4.8 billion loan will resume in early March."

Cairo and the IMF agreed in principle last November on the loan, based on an earlier version of the reform programme, but talks were suspended in December at Egypt's behest due to street violence. Any IMF deal would involve unpopular austerity measures just as Egyptians vote in four-stage parliamentary elections due to be held from April until late June.

Under the latest programme, the government will impose a 0.001 percent levy on stock market transactions, according to excerpts of the programme seen by Reuters, and corporate tax will be standardised at 25 percent.

Current rates are 20 and 25 percent, meaning tax bills for some firms will rise at a time of great economic hardship.

The programme also seeks to end the alarming slide in foreign currency reserves as the central bank has tried to prop up the Egyptian pound in recent years. It targets reserves of $19 billion by the end of June, climbing to $22.5 billion a year later.

Reserves tumbled to $13.6 billon in January from $36 billion before the overthrow of president Hosni Mubarak in February 2011, and the Egyptian pound has fallen 8.2 percent since the central bank began auctioning dollars at the end of December.

CAUTIOUS ECONOMISTS

Economists expressed caution about the figures, and whether Egypt could secure IMF help by the end of the financial year in June. "They had their targets before and they didn't reach them," said Mona Mansour, chief economist at CI Capital.

"Maybe they are targeting to have the IMF programme by then, but I think it will be difficult. Other than that, they may have an agreement with regional countries," she said.

Egypt has secured funding from Qatar in recent months but this has not halted the fall in reserves or the drop in the pound. On top of the economic crisis, Egypt is in political turmoil with the Islamist government of President Mohamed Mursi in conflict with the liberal and leftist opposition.

Some opposition politicians want to boycott the elections, which are supposed to complete Egypt's transition to democracy after Mubarak's fall, over a range of disputes including a new constitution produced by an Islamist-dominated assembly.

Mansour noted that the loan talks had been repeatedly delayed during the political turmoil. "The situation has to be calmer politically," she said.

The revised reform programme confirmed the daunting budget problems that the government faces. It targets a deficit for this financial year of 189.7 billion Egyptian pounds, or a huge 10.9 percent of total economic output.

Even this assumes economic reforms are made and the deficit would hit 12.3 percent of GDP without such action, it forecast.

The government gave scant details on personal income tax. The threshold below which Egyptians pay the lowest rate tax would be raised, but it gave no details of any changes in rates paid by higher earners.

Source: http://news.yahoo.com/egypt-reform-plan-targets-recovery-forex-reserves-124644374--business.html

oscars red carpet jennifer lopez wardrobe malfunction hugo hugo nfl combine 84th annual academy awards beginners

Farrakhan focuses on economics in Chicago speech (Providence Journal)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/287117016?client_source=feed&format=rss

george strait how i met your mother Jordan Pruitt real housewives of new jersey Kanye West sex tape emmys emmys

Africa Mongolia to Host UN World Environment Day 2013

  • Asia Times - Saturday 23rd February, 2013

    By Alexandra Kazakova Last year's violence in the town of Janaozen has created a significantly more oppressive environment in Kazakhstan, according to human rights defenders and analysts ...

  • Rate of US-Russian nuke disarmament slows

    Asia Times - Saturday 23rd February, 2013

    By Carey L Biron WASHINGTON - Although the United States and Russia have massively reduced their collective number of nuclear weapons since the heyday of the Cold War, the rate of that reduction ...

  • Russia-Uzbekistan rowjeopardizes bilateral ties

    Asia Times - Saturday 23rd February, 2013

    investigation, O'zdunorbita continuously violated national legislation by illicitly operating 48 base stations in various parts of the country, including 24 stations based out of Tashkent. ...

  • Russias gas grip worries US senator

    Asia Times - Saturday 23rd February, 2013

    By Margarita Assenova United States Senator Richard Lugar has urged the Obama administration to break Russia's energy monopoly in Europe and called on congress to lift limitations on ...

  • Crime pays in Kyrgyzstan

    Asia Times - Saturday 23rd February, 2013

    By Chris Rickleton BISHKEK - One morning last year in Bishkek, Kyrgyzstan, Dilnoza awoke to find her brand-new Toyota Corolla missing. She knew immediately whom to call, and it wasn't her ...

  • Russia plays alongwith Sakhalin pipeline project

    Asia Times - Saturday 23rd February, 2013

    By Sergei Blagov Russia's gas monopoly, Gazprom, has apparently ruled out the possibility of building a subsea Sakhalin-Japan natural gas pipeline. However, the continuation of talks on ...

  • Tamerlane through Central Asian eyes

    Asia Times - Saturday 23rd February, 2013

    Tamerlane through Central Asian eyes The Legendary Biographies of Tamerlane: Islam and Heroic Apocrypha in Central Asia by Ron SelaReviewed by Dmitry Shlapentokh This well-researched book ...

  • CIS nations set date for free-trade zone

    Asia Times - Saturday 23rd February, 2013

    By Sergei Blagov The latest top-level meeting of the oldest post-Soviet grouping, the Commonwealth of Independent States (CIS), pledged to enact their free-trade arrangements next year. However, ...

  • Siberia placed to be the new Middle East

    Asia Times - Saturday 23rd February, 2013

    originates from a volatile region with a lion's share of the supply passing through narrow waterways that could easily be sealed off to tankers. More than any other market factors, it is ...

  • Salafists challenge Kazakh future

    Asia Times - Saturday 23rd February, 2013

    Salafists challenge Kazakh future By Jacob Zenn Kazakhstan has experienced a rise in militant activity carried out by Salafist groups on its territory and periphery since late 2011. The ...

  • Kyrgyzstan flirts with Russian ambitions

    Asia Times - Saturday 23rd February, 2013

    By Dmitry Shlapentokh Recent agreements signed between Russian President Vladimir Putin and his Kyrgyz Republic counterpart, Almazbek Atambayev, are replete with mutual benefits. Russia affirmed ...

  • Jewelry-making part of family day at McClung Museum

    General Sources - Saturday 23rd February, 2013

    McClung Museum invites the public to glimpse treasures from the past and create their own jewelry during a free family day at the University of Tennessee this ...

  • Azerbaijan and Turkey can produce anti-tank missiles

    News.Az - Saturday 23rd February, 2013

    Azerbaijan can produce UMTAS and OMTAS anti-tank missiles with Turkey, Turkish defence industry delegation told APA at 11th International Defence Exhibition (IDEX - 2013) exhibition. Azerbaijan is ...

  • Sport in Azerbaijan developed after Heydar Aliyevs advent to power - MP

    News.Az - Saturday 23rd February, 2013

    Azerbaijani sport has achieved great success in the international arena. The statement came from the deputy executive secretary of the ruling party, MP Mubariz Gurbanli at a presentation of book ...

  • Azerbaijan claims for hosting Islamic sport games in 2017

    News.Az - Saturday 23rd February, 2013

    Azerbaijan has turned into one of the world sport centers able to host major sport events. The statement came from Minister of Youth and Sports of Azerbaijan Azad Rahimov speaking at the ...

  • Azeri boxers reach semifinal of Strandja tournament in Bulgaria

    News.Az - Saturday 23rd February, 2013

    Four Azerbaijani boxers have qualified for the semifinal of the Strandja tournament in Bulgaria. On the way to the final, Elvin Isayev weighing in at 64kg, Munasib Mammadov at 49kg, Javid ...

  • Azerbaijan Macedonia sign memo on audit services

    News.Az - Saturday 23rd February, 2013

    AzerTAj reports. The memorandum is aimed at fostering closer relations between Azerbaijan and Macedonia, as well as improving the quality of audit ...

  • Azerbaijan to form Labour Resources Development Agency

    News.Az - Saturday 23rd February, 2013

    The Ministry of Labour and Social Protection considers establishing the Labour Resources Development Agency. A draft regulation of the agency has already been developed and will be updated in ...

  • KSA signs water and sewerage deal with Azerbaijan

    Construction Week Online - Friday 22nd February, 2013

    The Saudi Fund for Development and Azerbaijan have signed the protocol of negotiations under the draft credit agreement on allocation of $35m for renovation and expansion of water supply and ...

  • Russian military told to fix deficiencies

    Middle East Times - Friday 22nd February, 2013

    Random checks of the Russian armed forces revealed a number of systemic shortcomings, General Staff chief Valery Gerasimov said. Combat alert checks were carried out in the Central and South ...

  • Source: http://www.turkmenistannews.net/index.php/sid/212780411/scat/929bcf2071e81801

    B H c mitt romney mark zuckerberg mark zuckerberg maurice jones drew

    Sunday, February 24, 2013

    How to customize the Google search background in Chrome: http://cnet.co/XuV6qW

    Sorry, Readability was unable to parse this page for content.

    Source: http://www.facebook.com/photo.php?fbid=10151554185177275&set=a.10150249764552275.377410.7155422274&type=1

    michael bay ninja turtles san antonio weather mike daisey nicollette sheridan apple dividend snow white and the huntsman snow white and the huntsman

    Google Nexus 7 Essentials Kit

    We are sorry, but the page you are looking for cannot be found.

    • If you typed the URL directly, please make sure the spelling is correct.
    • If you clicked on a link to get here, we must have moved the content.
      Please try our store search box above to search for an item.
    • If you need further assistance, please contact support: here

    Linux web1.incipio.com 2.6.32-279.14.1.el6.x86_64 #1 SMP Mon Oct 15 13:44:51 EDT 2012 x86_64

    Source: http://www.incipio.com/google-nexus-7-essentials-kit-5117.html

    whitney houston dead 2012 whitney houston passed away heartbreak hotel don cornelius whitney houston i will always love you breaking news whitney houston carmen