Wednesday, October 30, 2013

Medical Magic Leads To Terror In 'Parasite'



Welcome to SymboGen, your friendly neighborhood medical company; have you stopped by for your tapeworm implant? Fair warning: There have been some unusual side effects ...


Health care has swallowed American headlines in recent years; besides the arguments over who deserves treatment to begin with, issues are emerging in pharmaceutical brand ethics, anti-vaccination activism, and the overuse of antibiotics. The war against disease is spreading against the smallest enemies of all.


In Parasite, Mira Grant imagines a near future in which genetically modified tapeworms are a universal health-care solution. Once implanted, the worm provides immune-system support, making its human host healthy for the duration of its life — though like any good piece of commodified progress, the worms have planned obsolescence and need to be replaced regularly.


Sal Mitchell owes her life to her parasite, which brought her out of a coma after a serious car accident. Unfortunately, her memories vanished, and her current personality is only 6 years old. She lives a life that's half lab rat and half surreal puberty, living at home, dating a doctor (though not one of hers), and relearning language and social idiosyncracies in a treading-water existence. Something's got to give — and does; people start contracting a bizarre sleepwalking sickness just as Sal starts getting cryptic messages about what she already suspects. This pandemic is no accident.


Though technobabble trips off everyone's tongues, Grant is most interested in the ethical implications of that technology, so advanced it really is indistinguishable from magic. She presents government and corporations not as monoliths, but as flawed systems whose participants are only as trustworthy or greedy as the individual in question. Those individual personalities are revealed in interludes (such as an interview with SymboGen's co-founder and the notes of their vanished head scientist) that suggest public perception as the true arena in which wars are fought — though they offer diminishing returns as the story unfolds.





Mira Grant's previous books include the Hugo Award-nominated Newsflesh series.



Orbit Books


Mira Grant's previous books include the Hugo Award-nominated Newsflesh series.


Orbit Books


But as the first of a series, Parasite often feels like groundwork: characters are dutifully introduced, horrors steadily unrolled, and ethical arguments sedately hashed out, so that even increasingly frequent zombie outbreaks can't stir up real urgency. An Everyperson can be a compelling center for a conspiracy story — but Sal's so slow on the uptake that we figure out plot twists far ahead of her. The suspense often stretches thin, and some of the most promising thematic parallels fizzle out in service of the plot. (It's telling that of the many horrors Sal faces, her tipping point comes when her parents ground her; it suggests a parallel with the parent state medical technology has become, but the full impact of the setup gets pushed aside by another burst of action.) And though it's a refreshing change for a thriller heroine to have a trustworthy boyfriend, many others in the supporting cast — the awkward family, the stalwart dog, the mysterious CEO, the mysterious scientist, the quirky girl — never quite come into focus.


Parasite succeeds most in capturing the frustration and administrative dread that's part and parcel of recovering from a traumatic medical incident. Being exposed to a zombie pandemic seems less dangerous to Sal than having to undergo the subsequent poking and prodding by indifferent doctors; it's a well-grounded medical wariness that gets at the heart of what the Parasitology series will be asking: What happens when the cure is worse than the disease?



Source: http://www.npr.org/2013/10/30/239167270/medical-magic-leads-to-terror-in-parasite?ft=1&f=1032
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Qigong can help fight fatigue in prostate cancer survivors

Qigong can help fight fatigue in prostate cancer survivors


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Contact: Joan Robinson
joan.robinson@springer.com
49-622-148-78130
Springer



Pilot study shows that older patients enjoy and benefit from this mind-body activity



The flowing movements and meditative exercises of the mind-body activity Qigong may help survivors of prostate cancer to combat fatigue. These are the findings of a trial study led by Dr. Anita Y. Kinney at the University of New Mexico Cancer Center and Dr. Rebecca Campo at the University of North Carolina at Chapel Hill. The study took place at the Huntsman Cancer Institute at the University of Utah, and was published in Springer's Journal of Cancer Survivorship.


Severe fatigue is one of the most common cancer-related symptoms reported by cancer survivors, particularly for prostate cancer survivors receiving androgen deprivation therapy (ADT). This subjective sense of physical, emotional or cognitive exhaustion may persist for months or years following treatment. It greatly diminishes survivors' quality of life by limiting their ability to perform daily activities and causes significant distress.


Because cancer patients are often advised to participate in physical activity as a nonpharmacological way to manage cancer-related fatigue and levels of distress, senior author Kinney and lead author Campo launched a trial study to determine if the mind-body activity Qigong holds any promise for older cancer survivors in this regard. Qigong is performed at a slow pace, is not overly physically exertive, and can even be performed sitting. It combines slow, flowing movements with coordinated deep breathing and meditative exercises.


Forty participants who suffered from high levels of fatigue were recruited for a 12-week randomized controlled trial. The group was on average 72 years old. Half of the group took part in Qigong classes, while the other participants attended stretching classes.


Qigong classes seemed to have been more popular with the participants, as its class attendance was higher than that of the stretching group. More importantly though, according to Kinney, "Qigong participants reported significant declines in how much fatigue or distress they experienced, compared to those who participated in the stretching class."


"Qigong may be an effective nonpharmacological intervention for the management of senior prostate cancer survivors' fatigue and distress," says Campo, who adds that further larger trials would be needed to confirm these benefits in older prostate cancer survivors and in racially and ethnically diverse populations.


###

Reference:

Campo, R.A., Kinney, A.Y. et al (2013). Levels of fatigue and distress in senior prostate cancer survivors enrolled in a 12-week randomized controlled trial of Qigong, Journal of Cancer Survivorship, DOI 10.1007/s11764-013-0315-5


The full-text article is available to journalists on request.



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Qigong can help fight fatigue in prostate cancer survivors


[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:

30-Oct-2013



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]


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Contact: Joan Robinson
joan.robinson@springer.com
49-622-148-78130
Springer



Pilot study shows that older patients enjoy and benefit from this mind-body activity



The flowing movements and meditative exercises of the mind-body activity Qigong may help survivors of prostate cancer to combat fatigue. These are the findings of a trial study led by Dr. Anita Y. Kinney at the University of New Mexico Cancer Center and Dr. Rebecca Campo at the University of North Carolina at Chapel Hill. The study took place at the Huntsman Cancer Institute at the University of Utah, and was published in Springer's Journal of Cancer Survivorship.


Severe fatigue is one of the most common cancer-related symptoms reported by cancer survivors, particularly for prostate cancer survivors receiving androgen deprivation therapy (ADT). This subjective sense of physical, emotional or cognitive exhaustion may persist for months or years following treatment. It greatly diminishes survivors' quality of life by limiting their ability to perform daily activities and causes significant distress.


Because cancer patients are often advised to participate in physical activity as a nonpharmacological way to manage cancer-related fatigue and levels of distress, senior author Kinney and lead author Campo launched a trial study to determine if the mind-body activity Qigong holds any promise for older cancer survivors in this regard. Qigong is performed at a slow pace, is not overly physically exertive, and can even be performed sitting. It combines slow, flowing movements with coordinated deep breathing and meditative exercises.


Forty participants who suffered from high levels of fatigue were recruited for a 12-week randomized controlled trial. The group was on average 72 years old. Half of the group took part in Qigong classes, while the other participants attended stretching classes.


Qigong classes seemed to have been more popular with the participants, as its class attendance was higher than that of the stretching group. More importantly though, according to Kinney, "Qigong participants reported significant declines in how much fatigue or distress they experienced, compared to those who participated in the stretching class."


"Qigong may be an effective nonpharmacological intervention for the management of senior prostate cancer survivors' fatigue and distress," says Campo, who adds that further larger trials would be needed to confirm these benefits in older prostate cancer survivors and in racially and ethnically diverse populations.


###

Reference:

Campo, R.A., Kinney, A.Y. et al (2013). Levels of fatigue and distress in senior prostate cancer survivors enrolled in a 12-week randomized controlled trial of Qigong, Journal of Cancer Survivorship, DOI 10.1007/s11764-013-0315-5


The full-text article is available to journalists on request.



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Source: http://www.eurekalert.org/pub_releases/2013-10/s-qch103013.php
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Contractor warned health site had limited testing

WASHINGTON (AP) — A major contractor behind the federal health insurance exchange website told the government last month it didn't have enough time to test its product.

CGI Federal also told the Centers for Medicare and Medicaid Services in a memo that it couldn't get access to computer logs that would have pinpointed potential problems. The contractor labeled that issue as "severe" as recently as June, and said a compressed schedule didn't allow enough time for adequate testing.

The House Committee on Oversight and Government Reform asked CGI Federal for the documents last week. It released them to the public late Tuesday.

The HealthCare.gov website is a key part of President Barack Obama's health care overhaul, but its high-profile failures have marred the site since it launched Oct. 1.

Associated PressSource: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-10-30-Health%20Overhaul-Problems-Warning/id-717dca321952439ab08f89710967a615
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Daniel Radcliffe Scores Lead Role in “Gold”

He’s one of the most diverse actors of his generation, and Daniel Radcliffe is gearing up to enter the world of (movie) politics.


The “Harry Potter” star will play British politician and former track and field star Sebastian Coe in the forthcoming James Watkins flick “Gold.”


Per the synopsis, “Sebastian Coe, obsessive and nurtured, is a quiet loner driven to the limit of endeavor by his ambitious father. Steve Ovett, effortless and natural, is a confident joker and outsider, fighting to prove himself in an elitist world.”


“Both are fueled by rivalry but burdened by the weight of expectation and fear of failure. Lovers, family loyalties and the human spirit are tested to breaking point in a relentless race for glory. Inspired by a crescendo of real-life events – this is a movie about winning, losing and the pursuit of immortality.”


Source: http://celebrity-gossip.net/daniel-radcliffe/daniel-radcliffe-scores-lead-role-%E2%80%9Cgold%E2%80%9D-952117
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BUSM researchers study epigenetic mechanisms of tumor metastasis for improved cancer therapy

BUSM researchers study epigenetic mechanisms of tumor metastasis for improved cancer therapy


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Contact: Gina Orlando
gina.orlando@bmc.org
617-638-8490
Boston University Medical Center





A review article by researchers at Boston University School of Medicine (BUSM) suggests that epigenetics may be a useful target to stop the growth, spread and relapse of cancer. The findings are published online in Volume 14 of the International Journal of Molecular Science.


The term epigenetics refers to the external modifications to DNA that turn genes "on" or "off." These modifications do not change the DNA sequence, but instead, they affect how cells read genes.


The researchers propose that epigenetic and other changes mediate the development of cancer progenitor cells. These cells represent the early stage of cancer cell development and can grow rapidly to become full-fledged cancer. According to the researchers, progression of different cancer stages and development of metastatic potential requires differentiation of these cancer progenitor cells.


"These findings are not only important in understanding how cancer progresses, but also help in understanding how cancer progenitor cells grow and differentiate via epigenetic regulators," said Sibaji Sarkar, PhD, instructor of medicine at BUSM.


Mutated cells are more vulnerable to the environment. Some of these mutations may alter epigenetic regulation in addition to epigenetic changes occurring by external and internal influences, which impacts gene expression and regulates cell behavior, playing a profound role when normal cells develop into progenitor cancer cells.


Sarkar and his colleagues hypothesize that when the progenitor cancer cells metastasize, rapid growth halts. When differentiation is complete, the rapid growth resumes.


The researchers believe that epigenetic mechanisms are involved in this process. Once a degree of metastatic form of cancer is achieved, the genes, which cause the change, become inactive and the genes causing rapid growth are again turned on.


"The acknowledgement of epigenetic changes as key regulators of this switching is expected to generate better epigenetic drugs. It has been suggested that epigenetic drug treatment in combination with standard chemotherapeutic drugs may have better outcomes in preventing and treating drug-resistant cancers," he added.


###

This study was funded in part by the American Cancer Society. Garrick Horn, Kimberly Moulton, Anuja Oza, Shannon Byler, Shannon Kokolus and Mckenna Longacre are co-authors of the review article.




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BUSM researchers study epigenetic mechanisms of tumor metastasis for improved cancer therapy


[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:

30-Oct-2013



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]


Share Share

Contact: Gina Orlando
gina.orlando@bmc.org
617-638-8490
Boston University Medical Center





A review article by researchers at Boston University School of Medicine (BUSM) suggests that epigenetics may be a useful target to stop the growth, spread and relapse of cancer. The findings are published online in Volume 14 of the International Journal of Molecular Science.


The term epigenetics refers to the external modifications to DNA that turn genes "on" or "off." These modifications do not change the DNA sequence, but instead, they affect how cells read genes.


The researchers propose that epigenetic and other changes mediate the development of cancer progenitor cells. These cells represent the early stage of cancer cell development and can grow rapidly to become full-fledged cancer. According to the researchers, progression of different cancer stages and development of metastatic potential requires differentiation of these cancer progenitor cells.


"These findings are not only important in understanding how cancer progresses, but also help in understanding how cancer progenitor cells grow and differentiate via epigenetic regulators," said Sibaji Sarkar, PhD, instructor of medicine at BUSM.


Mutated cells are more vulnerable to the environment. Some of these mutations may alter epigenetic regulation in addition to epigenetic changes occurring by external and internal influences, which impacts gene expression and regulates cell behavior, playing a profound role when normal cells develop into progenitor cancer cells.


Sarkar and his colleagues hypothesize that when the progenitor cancer cells metastasize, rapid growth halts. When differentiation is complete, the rapid growth resumes.


The researchers believe that epigenetic mechanisms are involved in this process. Once a degree of metastatic form of cancer is achieved, the genes, which cause the change, become inactive and the genes causing rapid growth are again turned on.


"The acknowledgement of epigenetic changes as key regulators of this switching is expected to generate better epigenetic drugs. It has been suggested that epigenetic drug treatment in combination with standard chemotherapeutic drugs may have better outcomes in preventing and treating drug-resistant cancers," he added.


###

This study was funded in part by the American Cancer Society. Garrick Horn, Kimberly Moulton, Anuja Oza, Shannon Byler, Shannon Kokolus and Mckenna Longacre are co-authors of the review article.




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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.




Source: http://www.eurekalert.org/pub_releases/2013-10/bumc-brs103013.php
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Dear Prudence: Chintzy Travel Companions


TUESDAY, APRIL 20, 2010, AT 6:19 PM
Tornado Kills at Least Five in Oklahoma






FRIDAY, APRIL 29, 2011, AT 3:07 PM
Obama Gets Firsthand Look at a Tornado Damage






TUESDAY, APRIL 20, 2010, AT 6:19 PM
Tornado Kills at Least Five in Oklahoma. Very long title. Long long long. Tornado Kills at Least Five in Oklahoma. Very long title. Long long long.






TUESDAY, APRIL 20, 2010, AT 6:19 PM
Tornado Kills at Least Five in Oklahoma. Very long title. Long long long. Tornado Kills at Least Five in Oklahoma. Very long title. Long long long.



Source: http://www.slate.com/articles/video/dear_prudence/2013/10/dear_prudence_video_chintzy_travel_companions.html
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A PVC Air Cannon Is Perfect for Scaring Trick or Treaters

You could make crazy DIY Halloween decorations to scare the creeps out of trick or treaters in your neighborhood. You could dress up drones as flying ghosts or ghoulish goblins to strike fear into child-sized candy beggars. You could be the cranky old man who turns his light off and seeps scare by ignoring costume wearers.

Read more...


    






Source: http://feeds.gawker.com/~r/gizmodo/full/~3/fq2UBV_emUo/a-pvc-air-cannon-is-perfect-for-scaring-trick-or-treate-1453729798
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